The story sees brother and sister Tom and Ellen Bowen as stars of a show "Every Night at Seven", a Broadway success. They are persuaded to take the show to London, capitalizing on the imminent royal wedding of Princess Elizabeth and Philip Mountbatten.

For as long as crime boss Albert Mendoza (Everett Sloane) has been running a notorious ring of hired hit men, District Attorney Martin Ferguson (Humphrey Bogart) has been hunting him down. But Ferguson cuts a deal with Mendoza's henchman Joe Rico (Ted De Corsia), and the mob boss is finally arrested. However, Rico dies mysteriously before he can testify against Mendoza.

Destruction Inc. is the 13th of 17 animated Technicolor short films based upon the DC Comics character of Superman. It was released on Christmas Day 1942.