Set in the early 1900s in the fictional Catfish Row section of Charleston, South Carolina, which serves as home to a black fishing community, the story focuses on the titular characters, crippled beggar Porgy, who travels about in a goat-drawn cart, and the drug-addicted Bess, who lives with stevedore Crown, the local bully.

On the outskirts of town, the hard-nosed Vienna owns a saloon frequented by the undesirables of the region, including Dancin’ Kid and his gang. Another patron of Vienna’s establishment is Johnny Guitar, a former gunslinger and her lover. When a heist is pulled in town that results in a man’s death, Emma Small, Vienna’s rival, rallies the townsfolk to take revenge on Vienna’s saloon – even without proof of her wrongdoing.