A series of adventures begins when Buster Keaton is mistaken for Dead Shot Dan, the evil bad guy.

When a disease turns all of humanity into the living dead, the last man on earth becomes a reluctant vampire hunter.

Snagglepuss adds a room to his house, hoping the rent he receives will finance a vacation trip to the South Seas. Lovely Lila, a Southern belle, becomes his new tenant. In no time, Snagglepuss finds himself moved into the spare room and Lila has the run of the house. When she demands new drapes, new decorating, and not one but two swimming pools, Snagglepuss rebels.