Morgan (Frank Shannon) pays off Randy (Smith Ballew) and Barry (Stanley Fields) with a promissory note to be collected at the Blake ranch. They arrive to find Mrs. Blake (Ruth Robinson) sick and without any money, her back taxes due, her ranch hands departed, and her son in need of an operation. With Randy attracted to Janet (Cecilia Parker) and Barry hoping to help Danny (Wally Albright), the two decide to stay.

There’s a deficit of good, honest women in the West, and Roy Whitman wants to change that. His solution is to bring a caravan of over 100 mail-order brides from Chicago to California. It will be a long, difficult and dangerous journey for the women. So Whitman hires hardened, cynical Buck Wyatt to be their guide across the inhospitable frontier. But as disaster strikes on the trail, Buck just might discover that these women are stronger than he thinks.