Due to a possible cholera epidemic onboard, passengers on a ship are forced to disembark at Pago Pago, a small village on a Pacific island where it incessantly rains. Among the stranded passengers are Sadie Thompson, a prostitute, and Alfred Davidson, a fanatic missionary who will try to redeem her.

Renowned for his excess, King Henry VIII (Charles Laughton) goes through a series of wives during his rule. With Anne Boleyn, his second wife, executed on charges of treason, King Henry weds maid Jane Seymour, but that marriage also ends in tragedy. Not one to be single for long, the king picks German-born Anne of Cleves as his bride, but their union lasts only months before an annulment is granted, and King Henry continues his string of spouses.