An Englishman (Leslie Howard) who has been studying painting in Paris for four years, is advised by his art teacher that his work is mediocre and second-rate, and that he lacks promise. So he returns to London, England to take up studies to become a medical doctor, but his older age and introspection make it difficult for him to keep up in his scholastic work. In England, he becomes infatuated - and then obsessed by a blonde, lower-class, slatternly and vulgar, Cockney-accented, illiterate tearoom waitress named Mildred Rogers (Bette Davis)

Through a fluke circumstance, a ruthless woman stumbles across a suitcase filled with $60,000, and is determined to hold onto it even if it means murder.

A young woman finds herself as the intended victim of a murder plot on a transatlantic flight from London to New York.