In his attempt to be the most powerful man in the world, Justin Taylor, leader of a sinister Ninja army, has become the largest narcotics smuggler in the orient. The U.S. Drug Enforcement Agency and the Hong Kong Police have joined forces with the CIA and a brilliant policewoman, the awesome Amazonia, to bring down Taylor by any means, at any cost.

Set in the early 1900s in the fictional Catfish Row section of Charleston, South Carolina, which serves as home to a black fishing community, the story focuses on the titular characters, crippled beggar Porgy, who travels about in a goat-drawn cart, and the drug-addicted Bess, who lives with stevedore Crown, the local bully.