Jeffrey Haywood wants to marry to Virginia Embrey. However, Virginia refused to marry unless her older sister, the hard-to-please Angelica gets married first. Angelica, in turn, finds every man she knows too dull and predictable, and for this reason prefers to stay single. Jeff then tries to make Angelica interested in the mild-mannered and timid Reggie Irving passing him off as a notorious playboy to intrigue her. He asks his friend Polly to teach Reggie “how to treat a woman right”, but he turns to be a disastrous learner.

The series follows the mystery-solving adventures of the Teen Angels—Brenda, Dee Dee and Taffy—and their friend Captain Caveman (or Cavey for short), a prehistoric caveman and superhero whom the girls discovered and thawed from a block of ice. The concept and general plot for the show was seen as a parody of "Charlie's Angels".

Playboy songwriter Brad Allen’s succession of romances annoys his neighbor, interior designer Jan Morrow, who shares a telephone party line with him and hears all his breezy routines.