Paul's second missionary journey is ending. He arrives in Corinth and meets Aquila and his wife Priscilla who become his fellow workers. After teaching in the synagogue, the Jews opposed him, so he goes out to the Gentiles. Priscilla and Aquila meet a Jew named Apollos whom they then taught him a more accurate picture of who Jesus was, and then he went on and helped all who believed in Jesus Christ and the salvation that comes from grace.

Some Jews began teaching that Gentiles could not be saved unless they were circumcised. Paul and Barnabas challenged them, and ultimately this dispute was brought before the Church in Jerusalem where the decision was made stating circumcision was not required due to references in the Old Testament, which presentated by James. Paul, who was in Antioch, spoke with Barnabas regarding meeting with the bretheren in all the cities the ministered in, to see how they were doing. Barnabas wanted to take John Mark with them, but Paul said no, so Mark went with Barnabas and Silas went with Paul.