A private school for young girls is scandalized when one spiteful student, Mary Tilford, accuses the two young women who run the school of having a lesbian relationship.

On the outskirts of town, the hard-nosed Vienna owns a saloon frequented by the undesirables of the region, including Dancin’ Kid and his gang. Another patron of Vienna’s establishment is Johnny Guitar, a former gunslinger and her lover. When a heist is pulled in town that results in a man’s death, Emma Small, Vienna’s rival, rallies the townsfolk to take revenge on Vienna’s saloon – even without proof of her wrongdoing.

Trapped on a remote island by a hurricane, a group discover a doctor has been experimenting on creating half sized humans. Unfortunately, his experiments have also created giant shrews, who when they have run out of small animals to eat, turn on the humans.