The film argues that sexually explicit materials corrupt young viewers and readers, leading to acts of violence and perverted attitudes regarding sex—including inclination toward homosexuality. Perversion for Profit was serious in its suggestion that pornography could erode the integrity of American culture.

A young girl named Burma attends a beach party with her boyfriend and after she smokes marijuana with a bunch of other girls, she gets pregnant and another girl drowns while skinny dipping in the ocean. Burma and her boyfriend go to work for the pusher in order to make money so they can get married. However, during a drug deal her boyfriend is killed leaving Burma to fend for herself. Burma then becomes a major narcotics pusher in her own right.

Paddlefoot is chosen to pilot a spacecraft due to his high dog IQ. However, when the spacecraft gets lost, Clutch and Spinner must journey to find him.